The study team

TOPPITS team lead

Professor Janet Wilson

The Chief Investigator is responsible for the overall running of the trial, and has certain responsibilities delegated to him/her from the Sponsor (The Newcastle upon Tyne Hospitals NHS Foundation Trust)


Newcastle Clinical Trials Unit

Gillian Watson

The Trial Manager co-ordinates the day-to-day management of the trial.  Gillian is based at the Newcastle Clinical Trials Unit, at Newcastle University, and is part of the Trial Management Group (TMG) for TOPPITS.  The TMG is responsible for overseeing trial progress.



Local Principal Investigators

The Principal Investigator has overall responsibility for the conduct of the study at a particular hospital.  The Principal Investigator at each site would be the main point of contact locally for those taking part in the study. 

There are six hospitals taking part in the TOPPITS study.  These are as follows:


Janet Wilson

  • Principal Investigator - The Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Email:
  • Telephone: (0191) 223 1086

Helen Cocks

  • Principal Investigator - Sunderland Royal Hospital (part of City Hospitals Sunderland NHS Foundation Trust)
  • Email:

Julian McGlashan

  • Principal Investigator - Nottingham University Hospitals NHS Trust
  • Email:
  • Telephone: 0115 9249924 Ext 63933

Kenneth MacKenzie

Yakubu Karagama

  • Principal Investigator - Manchester Royal Infirmary (part of Central Manchester University Hospitals NHS Foundation Trust)
  • Email:
  • Telephone: 0161 276 8511

Meredydd (Mered) Harries

  • Principal Investigator - Royal Sussex County Hospital (part of Brighton and Sussex University Hospitals NHS Trust)
  • Email:
  • Telephone: 01273 696955 Ext 4812

Declan Costello

  • Principal Investigator - Queen Elizabeth Hospital, Birmingham (part of University Hospitals Birmingham NHS Foundation Trust)
  • Email:

Sadie Khwaja

  • Principal Investigator at Stepping Hill Hospital, Stockport (part of Stockport NHS Foundation Trust)
  • Email: